Friday, March 2, 2012

What is Cancer?


Cancer is the general name for a group of more than 100 diseases in which cells in a part of the body begin to grow out of control. Although there are many kinds of cancer, they all start because abnormal cells grow out of control. Untreated cancers can cause serious illness and even death.

Normal Cells in the Body

The body is made up of trillions of living cells. Normal body cells grow, divide, and die in an orderly fashion. During the early years of a person's life, normal cells divide faster to allow the person to grow. After the person becomes an adult, most cells divide only to replace worn-out or dying cells or to repair injuries.

How Cancer Starts?

Cancer begins when cells in a part of the body start to grow out of control. There are many kinds of cancer, but they all start because of out-of-control growth of abnormal cells.

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Cancer cell growth is different from normal cell growth. Instead of dying, cancer cells continue to grow and form new, abnormal cells. Cancer cells can also invade (grow into) other tissues, something that normal cells cannot do. Growing out of control and invading other tissues are what makes a cell a cancer cell.

Cells become cancer cells because of damage to DNA. DNA is in every cell and directs all its actions. In a normal cell, when DNA gets damaged the cell either repairs the damage or the cell dies. In cancer cells, the damaged DNA is not repaired, but the cell doesn't die like it should. Instead, this cell goes on making new cells that the body does not need. These new cells will all have the same damaged DNA as the first cell does. 

People can inherit damaged DNA, but most DNA damage is caused by mistakes that happen while the normal cell is reproducing or by something in our environment. Sometimes the cause of the DNA damage is something obvious, like cigarette smoking. But often no clear cause is found. 

Cancer harms the body when damaged cells divide uncontrollably to form lumps or masses of tissue called tumors (except in the case of leukemia where cancer prohibits normal blood function by abnormal cell division in the blood stream). Tumors can grow and interfere with the digestive, nervous, and circulatory systems, and they can release hormones that alter body function. Tumors that stay in one spot and demonstrate limited growth are generally considered to be benign.

More dangerous, or malignant, tumors form when two things occur:
  1. A cancerous cell manages to move throughout the body using the blood or lymph systems, destroying healthy tissue in a process called invasion
  2. That cell manages to divide and grow, making new blood vessels to feed itself in a process called angiogenesis.

How Cancer Spreads?

Cancer cells often travel to other parts of the body, where they begin to grow and form new tumors that replace normal tissue. This process is called metastasis. It happens when the cancer cells get into the bloodstream or lymph vessels of our body.  No matter where a cancer may spread, it is always named for the place where it started.

For example, breast cancer that has spread to the liver is still called breast cancer, not liver cancer. Likewise, prostate cancer that has spread to the bone is metastatic prostate cancer, not bone cancer.

Different types of cancer can behave very differently. For example, lung cancer and breast cancer are very different diseases. They grow at different rates and respond to different treatments. That is why people with cancer need treatment that is aimed at their particular kind of cancer. 

Not all tumors are cancerous. Tumors that aren't cancer are called benign. Benign tumors can cause problems – they can grow very large and press on healthy organs and tissues. But they cannot grow into (invade) other tissues. Because they can't invade, they also can't spread to other parts of the body (metastasize). These tumors are almost never life threatening. 

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Video Presentation

A short, 3D, animated introduction to cancer, created by BioDigital Systems:


Cancers Classification

There are five broad groups that are used to classify cancer.
  1. Carcinomas are characterized by cells that cover internal and external parts of the body such as lung, breast, and colon cancer.
  2. Sarcomas are characterized by cells that are located in bone, cartilage, fat, connective tissue, muscle, and other supportive tissues.
  3. Lymphomas are cancers that begin in the lymph nodes and immune system tissues.
  4. Leukemias are cancers that begin in the bone marrow and often accumulate in the bloodstream.
  5. Adenomas are cancers that arise in the thyroid, the pituitary gland, the adrenal gland, and other glandular tissues.

Cancers are often referred to by terms that contain a prefix related to the cell type in which the cancer originated and a suffix such as -sarcoma, -carcinoma, or just -oma. Common prefixes include:
  • Adeno- = gland
  • Chondro- = cartilage
  • Erythro- = red blood cell
  • Hemangio- = blood vessels
  • Hepato- = liver
  • Lipo- = fat
  • Lympho- = white blood cell
  • Melano- = pigment cell
  • Myelo- = bone marrow
  • Myo- = muscle
  • Osteo- = bone
  • Uro- = bladder
  • Retino- = eye
  • Neuro- = brain

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General Symptoms

Some of the following are symptoms that can be associated with cancer. The acronym, C.A.U.T.I.O.N., can remind us of the most common warning signs of cancer.
  • C - Change in bowel or bladder habits
  • A - A sore that does not heal
  • U - Unusual bleeding or discharge
  • T - Thickening or lump in the breast or any part of the body
  • I - Indigestion or difficulty swallowing
  • O - Obvious change in a wart or mole
  • N - Nagging cough or hoarseness

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Sources and Additional Information:



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