Showing posts with label natural remedy. Show all posts
Showing posts with label natural remedy. Show all posts

Friday, September 9, 2011

May Regular Drinking of Green Tea Prevent Pancreatic Cancer?


Green Tea – Magic Drink

Today, millions of people drink tea around the world, and it is now considered as one of the most widely consumed beverages in the world, second after drinking water. Multiple studies confirm the Eastern Medicine conclusions that drinking green tea (Camellia Sinesis) in particular has many outstanding benefits for your health. Green tea is a botanical that has been shown to protect people from many types of cancer, reduces inflammation, helps protect the liver, boosts metabolism and shows many other positive health effects.

There are three main varieties of tea — green, black, and oolong. The difference between the teas is in their processing. Green tea is made from unfermented leaves and reportedly contains the highest concentration of powerful antioxidants called polyphenols.

Antioxidants are substances that scavenge free radicals — damaging compounds in the body that alter cells, tamper with DNA (genetic material), and even cause cell death. Free radicals occur naturally in the body, but environmental toxins (including ultraviolet rays from the sun, radiation, cigarette smoke, and air pollution) also give rise to these damaging particles. Many scientists believe that free radicals contribute to the aging process as well as the development of a number of health problems, including cancer and heart disease. Antioxidants such as polyphenols in green tea can neutralize free radicals and may reduce or even help prevent some of the damage they cause.

Green tea has been consumed throughout the ages in India, China, Japan, and Thailand. In traditional Chinese and Indian medicine, practitioners used green tea as a stimulant, diuretic (to promote the excretion of urine), astringent (to control bleeding and help heal wounds), and to improve heart health. Other traditional uses of green tea include treating flatulence (gas), regulating body temperature and blood sugar, promoting digestion, and improving mental processes.

Green tea and pancreatic cancer

Green tea has so many health related advantages for humans, so it is not surprising that medical scientists are trying to look if it can be useful for pancreatic cancer prevention. Pancreatic cancer is famous by its difficulties and diagnostics, so in many cases, it is identified at the moment when the tumor is incurable. Therefore, it so important to identify ways of preventing this deadly disease, or, actually, decreasing the risk of getting it.

In the recent article "Green tea and the risk of pancreatic cancer and colon cancer," the group of researchers from Columbia University examined the question of the effectiveness of green tea as a remedy against certain types of cancer. This is a preliminary study and researchers admitted that the results are not statistically conclusive yet, suggesting to complement it with additional researches on animal and human. However, the results are quite positive, and may lay a trail to the future studies and consumer recommendations.

Testing the hypothesis of the ability of green tea regular consumption to influence the risk of getting several types of cancer, the researchers conducted extensive study in Shanghai, China. The research team found the direct correlation between drinking green tea and cancer development rates: the higher consumption of green tea led to the lower the risk of cancer. Therefore, it seems that green tea can, in fact, reduce the incidence of both colon and pancreatic cancer, which is especially important for the people having certain predisposition to the tumor development.

Another study has been performed, looking for the causal relationship between green tea drinking and risk of development of pancreatic cancer in particular. And the results were also encouraging, showing the substantial health related benefits. Interesting that the study showed general difference in results - significantly higher positive effect has been observed among females, where the risk of pancreatic cancer decreased 50%, while male green tea drinkers has shown just 37% of the risk decrease.

Definitely, more studies are needed, but based on these results, and general benefits of Green Tea, I would say that it is highly recommended to be included in your daily diet, especially when you read its health benefits for other functional systems of your body and mind.

Other health benefits

Bladder cancer
Only a few clinical studies have examined the relationship between bladder cancer and green tea consumption. In one study that compared people with and without bladder cancer, researchers found that women who drank black tea and powdered green tea were less likely to develop bladder cancer. A follow-up clinical study by the same group of researchers revealed that bladder cancer patients (particularly men) who drank green tea had a substantially better 5-year survival rate than those who did not.

Breast cancer

Clinical studies in animals and test tubes suggest that polyphenols in green tea inhibit the growth of breast cancer cells. In one study of 472 women with various stages of breast cancer, researchers found that women who consumed the most green tea experienced the least spread of cancer (particularly premenopausal women in the early stages of breast cancer). They also found that women with early stages of the disease who drank at least 5 cups of tea every day before being diagnosed with cancer were less likely to suffer recurrences of the disease after completion of treatment. However, women with late stages of breast cancer experienced little or no improvement from drinking green tea. In terms of breast cancer prevention, the studies are inconclusive.

Ovarian cancer

 In a clinical study conducted on ovarian cancer patients in China, researchers found that women who drank at least one cup of green tea per day survived longer with the disease than those who didn’t drink green tea. In fact, those who drank the most tea, lived the longest.

Prostate cancer

 Laboratory studies have found that green tea extracts prevent the growth of prostate cancer cells in test tubes. In a large clinical study conducted in Southeast China researchers found that the risk of prostate cancer declined with increasing frequency, duration and quantity of green tea consumption.

Skin cancer


The main polyphenol in green tea is epigallocatechin gallate (EGCG). Scientific studies suggest that EGCG and green tea polyphenols have anti-inflammatory and anti-cancer properties that may help prevent the onset and growth of skin tumors.

Inflammatory Bowel Disease (IBD)

Green tea may help reduce inflammation associated with Crohn’s disease and ulcerative colitis, the two types of IBD. If green tea proves to be helpful for preventing colon cancer, this would be an added benefit for those with IBD because they are at risk for colon cancer.

Diabetes

Green tea has been used traditionally to control blood sugar in the body. Animal studies suggest that green tea may help prevent the development of type 1 diabetes and slow the progression once it has developed. People with type 1 diabetes produce little or no insulin, a hormone that converts glucose (sugar), starches, and other foods into energy needed for daily life. Green tea may help regulate glucose in the body. A few small clinical studies have found that daily supplementation of the diet with green tea-extract powder lowered the hemoglobin A1c level in individuals with borderline diabetes.

Liver disease

Population-based clinical studies have shown that men who drink more than 10 cups of green tea per day are less likely to develop disorders of the liver. Green tea also seems to protect the liver from the damaging effects of toxic substances such as alcohol. Animal studies have shown that green tea helps protect against the development of liver tumors in mice.
Results from several animal and human studies suggest that one of the polyphenols present in green tea, known as catechin, may help treat viral hepatitis (inflammation of the liver from a virus). In these studies, catechin was isolated from green tea and used in very high concentrations. It is not clear whether green tea (which contains a lower concentration of catechins) confers these same benefits to people with hepatitis.

Heart Disease

Green tea also benefits your heart. A Japanese study found that drinking four cups of green tea may reduce the severity of coronary heart disease. A similar Dutch study found that green tea consumption correlated with less clogging of the coronary arteries. Because the antioxidants in green tea are dilators, consuming more green tea improves the flexibility of blood vessels and may make them less likely to become clogged. 

Weight loss

Clinical studies suggest that green tea extract may boost metabolism and help burn fat. One study confirmed that the combination of green tea and caffeine improved weight loss and maintenance in overweight and moderately obese individuals. Some researchers speculate that substances in green tea known as polyphenols, specifically the catechins, are responsible for the herb’s fat-burning effect. Studies in Japan and the Netherlands have supported this claim. Participants in the Dutch study who drank the most green tea lost the most weight and body fat, had lower blood pressure, and had lower “bad” cholesterol.

Dosage

Depending on the brand, 2 - 3 cups of green tea per day (for a total of 240 - 320 mg polyphenols) or 100 - 750 mg per day of standardized green tea extract is recommended. Caffeine-free products are available and recommended.

Precautions

The use of herbs is a time-honored approach to strengthening the body and treating disease. However, herbs contain active substances that can trigger side effects and interact with other herbs, supplements, or medications. For these reasons, people should take herbs with care, under the supervision of a practitioner knowledgeable in the field of botanical medicine.

People who drink excessive amounts of caffeine (including caffeine from green tea) for prolonged periods of time may experience irritability, insomnia, heart palpitations, and dizziness. Caffeine overdose can cause nausea, vomiting, diarrhea, headaches, and loss of appetite. If you are drinking a lot of tea and start to vomit or have abdominal spasms, you may have caffeine poisoning. If your symptoms are severe, lower your caffeine intake and see your health care provider.

Possible Interactions

If you are being treated with any of the following medications, you should not drink green tea or take green tea extract without first talking to your health care provider:
Adenosine -- Green tea may inhibit the actions of adenosine, a medication given in the hospital for an irregular (and usually unstable) heart rhythm.
Antibiotics, Beta-lactam -- Green tea may increase the effectiveness of beta-lactam antibiotics by reducing bacterial resistance to treatment.
Benzodiazepines -- Caffeine (including caffeine from green tea) has been shown to reduce the sedative effects of benzodiazepines (medications commonly used to treat anxiety, such as diazepam and lorazepam).
Beta-blockers, Propranolol, and Metoprolol -- Caffeine (including caffeine from green tea) may increase blood pressure in people taking propranolol and metoprolol (medications used to treat high blood pressure and heart disease).
Blood Thinning Medications (Including Aspirin) -- People who take warfarin, a blood thinning medication, should not drink green tea. Since green tea contains vitamin K, it can make warfarin ineffective. Meanwhile, you should not mix green tea and aspirin because they both prevent platelets from clotting. Using the two together may increase your risk of bleeding.
Chemotherapy -- The combination of green tea and chemotherapy medications, specifically doxorubicin and tamoxifen, increased the effectiveness of these medications in laboratory tests. However, these results have not yet been demonstrated in studies on people. On the other hand, there have been reports of both green and black tea extracts stimulating a gene in prostate cancer cells that may cause them to be less sensitive to chemotherapy drugs. Given this potential interaction, people should not drink black and green tea (as well as extracts of these teas) while receiving chemotherapy for prostate cancer in particular.
Clozapine -- The antipsychotic effects of the medication clozapine may be reduced if taken fewer than 40 minutes after drinking green tea.
Ephedrine -- When taken together with ephedrine, green tea may cause agitation, tremors, insomnia, and weight loss.
Lithium -- Green tea has been shown to reduce blood levels of lithium (a medication used to treat manic/depression).
Monoamine Oxidase Inhibitors (MAOIs) -- Green tea may cause a severe increase in blood pressure (called a "hypertensive crisis") when taken together with MAOIs, which are used to treat depression. Examples of MAOIs include phenelzine and tranylcypromine.
Oral Contraceptives -- Oral contraceptives can prolong the amount of time caffeine stays in the body and may increase its stimulating effects.
Phenylpropanolamine -- A combination of caffeine (including caffeine from green tea) and phenylpropanolamine (an ingredient used in many over-the-counter and prescription cough and cold medications and weight loss products) can cause mania and a severe increase in blood pressure. The FDA issued a public health advisory in November 2000 to warn people of the risk of bleeding in the brain from use of this medication and has strongly urged all manufacturers of this drug to remove it from the market.

Useful Tips

  • Allow tea to steep for three to five minutes to bring out its catechins.
  • The best way to get the catechins and other flavonoids in tea is to drink it freshly brewed. Decaffeinated, bottled ready-to-drink tea preparations, and instant teas have less of these compounds.
  • Tea can impede the absorption of iron from fruits and vegetables. Adding lemon or milk or drinking tea between meals will counteract this problem.

Sources and Additional Information:



Sunday, July 3, 2011

Nigella sativa extract may prevent pancreatic cancer

Overview

Middle Eastern herbal seed called Nigella sativa may be used to prevent development or recurrence of pancreatic cancer a new study presented at the AACR 100th Annual Meeting 2009 in Denver suggests. The study showed that thymoquinone a major ingredient found in the oil extract from Nigella sativa inhibited expression of a number of inflammatory factors that are associated with development of pancreatic cancer.

Nigella sativa has already been found to kill pancreatic cancer cells and early studies showed it has anti cancer effects on prostate and colon cancers according to a press release by Thomas Jefferson University. The seed and oil of the herb have been used in traditional medicine by many Middle Eastern and Asian countries for thousands of years to treat a number of diseases including immune and inflammatory diseases.

Historical Evidence

Black cumin seeds were found in the tomb of Egyptian Pharaoh Tutankhamun, who ruled Egypt from 1333 BC to 1324 BC. The Egyptians supposedly put the seeds in his tomb so that he may have excellent health in the afterlife.

 The historical references to these seeds are also found in some of the oldest religious and medical texts. For example, it is referred to as ‘Melanthion’ by Hippocrates and Dioscorides, while the Bible describes it as the ‘curative black cumin’. It is, therefore, no wonder that they were thought to be worthy accompaniments in the ‘From Life here to Eternity’ by the pharaoh as described earlier.

The black cumin herb goes by many different names. For example, in old Latin it is called as ‘Panacea’ meaning ‘cure all’ while in Arabic it is termed as ‘Habbah Sawda’ or ‘Habbat el Baraka’ translated as ‘Seeds of blessing’. In India it is called as Kalonji while in China it is referred as Hak Jung Chou.

Several sources claim that Cleopatra used black cumin preparations for maintaining her health, beauty and vitality.

The most often quoted historical references come from ancient Islamic literature, wherein the black cumin is regarded the greatest medicinal plant to ever exist. Prophet Muhammad has once mentioned that the black cumin seed is capable of curing every disease except death. He said:

“Hold on to the use of the black seed, for it has the cure for every illness except death.”

Ancient Greek records say that the great physician Dioskorides used black cumin to treat and cure a variety of illnesses including intestinal parasites, toothaches, headaches, respiratory congestion and amenorrhea. He also used it as a diuretic and to promote milk production.

Hippocrates (460 BC – 370 BC) used Black Cumin for the treatment of liver and digestive disorders.

The Cannon of Medicine by Ibn Sina (Avicenna, 980 – 1037), considered by many as the greatest book in the history of ancient medicine refers to black cumin seed as “that which stimulates the body’s energy and helps recover from fatigue or dispiritedness.”

Modern Use

Nigella sativa has a rich composition of proteins, minerals, carbohydrates and fats. Almost all of its fat content is in the form of omega-3 and omega-6 fatty acids - which are very important for good overall health and a sound immune system. It also has around 15 amino acids, the building blocks of protein, 9 of which are the essential amino acids. It is most recognizably in Naan Bread.

The nigella sativa seed is known by various names, including kalo jira, kalo jeera, kali jeera.
  • Black cumin
  • Black caraway
  • Black onion seed
  • Black seed
  • Fennel flower
  • Roman coriander
  • Kalonji
Other names mistakenly used are onion seed and black sesame, and although these look similar to nigella sativa, they are not the same seed.

Black seed (Nigella sativa) is an annual flowering plant, native to southwest Asia, which has been used primarily in candies and liquors, as well as medicinally. Multiple studies suggest that black seed may decrease allergies. Black seed has also been studied for use in cancer, immune disorders, inflammation, stomach and respiratory conditions, and for women's health.

Nigella sativa and Pancreatic Cancer

For the study Dr. Hwyda Arafat at the Jefferson Medical College of Thomas Jefferson University and the Jefferson Pancreatic Biliary Related Cancers Center and colleagues compared thymoquinone and trichostatin A which is an inhibitor of histone deacetylases that are implicated in inflammatory associated cancers for their anti inflammatory properties. In pancreatic ductal adenocarcinoma PDA cells thymoquinone was found to almost completely knock out the expression of several inflammatory cytokines including TNF alpha interleukin 1beta interleukin 8 Cox 2 and MCP 1 an effect that was superior to that of trichostatin A.

The researchers found thymoquinone also inhibited the activation and synthesis of NF kappaB a factor that has been implicated in inflammation associated cancer. NF kappaB is activated in pancreatic cancer cells and may contribute to pancreatic cancer s resistance to chemotherapy. Additionally animal models of pancreatic cancer treated with thymoquinone had 67 percent of their tumors significantly shrunken and the levels of pro inflammatory cytokines in the tumors significantly reduced. Inflammation is implicated in several solid tumor malignancies. Pancreatic cancer killing 32 000 people in the United States each year has some association with chronic pancreatitis.

The researchers suggested that Nigella sativa may help people with chronic pancreatitis and those who are at high risk of devolvement or recurrence of pancreatic cancer.

Dosing

There are no scientific recommendations developed yet to advice on the dosage to maximize the positive effects of pancreatic cancer prevention, therefore the general guidelines for the other health issues treatment could be applied:
  • Black seed capsules at a dose of 40 to 80 milligrams/kilogram have been used daily for the treatment of allergies.
  • Black seed oil has been taken by mouth and used on the skin for the treatment of allergies, arthritis, anxiety, bruises, cold symptoms, diarrhea, headache, high blood pressure, flu, muscle soreness, rheumatic disease, sinus infection, and stomach disorders.
  • Black seed oil has been used on the scalp for hair loss, on the skin for the treatment of fungal infections, rubbed on the back and chest for asthma and cough, massaged on the abdomen for colic, dripped in the ear for earache, and rubbed on the forehead and surrounding facial areas for treatment of headache.
  • The vapor of black seed oil has been inhaled for the treatment of acne, asthma, cough, and sinusitis.
Safety

Allergies
  • Avoid with a known allergy or sensitivity to black seed. Skin irritation may occur after use of black seed or black seed oil applied to the skin.
Side Effects and Warnings
  • Black seed is generally safe when taken by mouth in amounts found in foods.
  • Use cautiously in patients with immune disorders due to its effects on the immune system.
  • Avoid in patients who are trying to conceive or who are pregnant as black seed may prevent uterine contractions and conception.
Pregnancy and Breastfeeding
  • Avoid in patients who are pregnant or breastfeeding or trying to conceive.
Interactions with Drugs
  • Black seed may inhibit conception and uterine contractions. Caution is advised in patients taking drugs used for fertility or to induce labor.
  • Black seed may have additive effects with antibiotics, drugs used to reduce inflammation, drugs used for parasites, drugs used for asthma, lipid lowering drugs, anti-cancer drugs, and drugs that affect the immune system.
Interactions with Herbs and Dietary Supplements
  • Black seed may inhibit conception and uterine contractions. Caution is advised in patients taking herbs or supplements used for fertility or to induce labor.
  • Black seed may have additive effects with antioxidants, antibiotics, herbs and supplements used to reduce inflammation, herbs and supplements used for parasites, herbs and supplements used for asthma, lipid lowering herbs and supplements, anti-cancer herbs and supplements, and herbs and supplements that affect the immune system.

Sources and Additional Information:


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